MolNFT v1 · #123058 · protein

Crystal structure of human HOOK3'S conserved hook domain

5J8E · Protein hook homolog 3: “Crystal structure of human HOOK3'S conserved hook domain”. X-ray diffraction, 1 pocket (best druggability 0.65). MolNFT v1 #123058 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5J8E
Type: protein
Length: 303 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein hook homolog 3
UniProt: Q86VS8
Pockets: 1 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 67% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein hook homolog 3	protein	150	69% helix, 0% strand	Q86VS8
B	Protein hook homolog 3	protein	153	66% helix, 0% strand	Q86VS8

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	393	0.65	0.79	39	empty

Interfaces

1 interface between chains.

A–B · 1618 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

5J8E · Crystal structure of human Hook3's conserved Hook domain · the same entry in another collection · chain A against A, TM-score 1.00
Q86VS8 · AlphaFold monomer V2.0 prediction for protein hook homolog 3 (Q86VS8) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86VS8
Elsewhere: RCSB PDB 5J8E · PDBe 5J8E · UniProt Q86VS8

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