MolNFT v1 · #12305 · protein

Crystal structure of antibody PC287

1KCU · PC287 immunoglobulin: “Crystal structure of antibody PC287”. X-ray diffraction, 5 pockets (best druggability 0.48). MolNFT v1 #12305 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1KCU
Type: protein
Length: 431 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: PC287 immunoglobulin
UniProt: P01837, Q9R1A4
Pockets: 5 · best druggability 0.48

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	PC287 immunoglobulin	protein	214	5% helix, 49% strand	P01837
H	PC287 immunoglobulin	protein	217	4% helix, 51% strand	Q9R1A4

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	245	0.48	0.74	36	empty
2	54	0.46	0.84	17	empty
3	92	0.33	0.73	23	empty
4	52	0.31	0.77	15	empty
5	60	0.29	0.74	20	empty

Interfaces

1 interface between chains.

L–H · 1925 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1KCU · Crystal structure of antibody PC287 · the same entry in another collection · chain L against L, TM-score 1.00
P01837 · AlphaFold monomer V2.0 prediction for immunoglobulin kappa constant (P01837) · a predicted model of the same protein · chain L against A, TM-score 0.49

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01837
Every structure of UniProt Q9R1A4
Elsewhere: RCSB PDB 1KCU · PDBe 1KCU · UniProt P01837 · UniProt Q9R1A4

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