MolNFT v1 · #123037 · protein

Faustovirus major capsid protein

5J7O: “Faustovirus major capsid protein”. X-ray diffraction, 20 pockets (best druggability 0.89). MolNFT v1 #123037 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5J7O
Type: protein
Length: 3,813 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Major capsid protein; Unknown
Pockets: 20 · best druggability 0.89

Structure

x-ray diffraction · 8 distinct chains · 17% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Major capsid protein	protein	611	17% helix, 42% strand	—
B	Major capsid protein	protein	616	17% helix, 42% strand	—
C	Major capsid protein	protein	616	17% helix, 42% strand	—
D	Major capsid protein	protein	610	17% helix, 43% strand	—
E	Major capsid protein	protein	614	16% helix, 43% strand	—
F	Major capsid protein	protein	622	16% helix, 42% strand	—
G, H, I, J, K	Unknown	protein	21	57% helix, 0% strand	—
L	Unknown	protein	19	58% helix, 0% strand	—

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	986	0.89	0.91	117	empty
2	989	0.89	0.90	117	empty
3	1141	0.86	0.86	78	empty
4	791	0.85	0.87	80	empty
5	910	0.84	0.86	84	empty

Interfaces

30 interfaces between chains.

E–F · 6521 Å² buried · 86 hydrogen bonds · protein-protein
B–C · 6481 Å² buried · 80 hydrogen bonds · protein-protein
A–C · 6443 Å² buried · 76 hydrogen bonds · protein-protein
A–B · 6367 Å² buried · 79 hydrogen bonds · protein-protein
D–F · 6355 Å² buried · 74 hydrogen bonds · protein-protein

Compared structures

5J7O · Faustovirus major capsid protein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5J7O · PDBe 5J7O

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