MolNFT v1 · #122936 · protein
Crystal structure of the L-ARGININE/AGMATINE antiporter from E. COLI at 2.2 angstroem resolution
5J4I: “Crystal structure of the L-ARGININE/AGMATINE antiporter from E. COLI at 2.2 angstroem resolution”. X-ray diffraction, 12 pockets (best druggability 0.78). MolNFT v1 #122936 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5J4I
- Type
- protein
- Length
- 874 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ARGININE/AGMATINE antiporter
- UniProt
- P60063
- Pockets
- 12 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | ARGININE/AGMATINE antiporter | protein | 437 | 80% helix, 0% strand | P60063 |
Pockets
12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 79 | 0.78 | 0.99 | 21 | empty |
| 2 | 464 | 0.71 | 0.81 | 37 | empty |
| 3 | 457 | 0.68 | 0.80 | 39 | empty |
| 4 | 155 | 0.50 | 0.77 | 19 | empty |
| 5 | 150 | 0.49 | 0.78 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 2648 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 5J4I · Crystal Structure of the L-arginine/agmatine antiporter from E. coli at 2.2 Angstroem… · the same entry in another collection · chain A against A, TM-score 1.00
- P60063 · AlphaFold monomer V2.0 prediction for ARGININE/AGMATINE antiporter (P60063) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60063
- Elsewhere: RCSB PDB 5J4I · PDBe 5J4I · UniProt P60063
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