MolNFT v1 · #12287 · protein
Crystal structure of the lambda repressor C-terminal domain octamer
1KCA · Repressor protein ci: “Crystal structure of the lambda repressor C-terminal domain octamer”. X-ray diffraction, 6 pockets (best druggability 0.85). MolNFT v1 #12287 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1KCA
- Type
- protein
- Length
- 808 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Repressor protein ci
- UniProt
- P03034
- Pockets
- 6 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 4% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | Repressor protein ci | protein | 101 | 4% helix, 40% strand | P03034 |
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1159 | 0.85 | 0.86 | 164 | empty |
| 2 | 211 | 0.65 | 0.84 | 43 | empty |
| 3 | 173 | 0.65 | 0.85 | 44 | empty |
| 4 | 97 | 0.55 | 0.85 | 24 | empty |
| 5 | 129 | 0.51 | 0.80 | 24 | empty |
Interfaces
16 interfaces between chains.
- A–B · 1002 Ų buried · 8 hydrogen bonds · protein-protein
- E–F · 996 Ų buried · 5 hydrogen bonds · protein-protein
- G–H · 967 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 962 Ų buried · 6 hydrogen bonds · protein-protein
- E–H · 424 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 1KCA · Crystal Structure of the lambda Repressor C-terminal Domain Octamer · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03034
- Elsewhere: RCSB PDB 1KCA · PDBe 1KCA · UniProt P03034
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