MolNFT v1 · #122836 · protein

Structure of the spectrin repeats 7 and 8 of the plakin domain of plectin

5J1G: “Structure of the spectrin repeats 7 and 8 of the plakin domain of plectin”. X-ray diffraction, 2 pockets (best druggability 0.72). MolNFT v1 #122836 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5J1G
Type: protein
Length: 457 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Plectin
UniProt: Q15149
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 85% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Plectin	protein	228	85% helix, 0% strand	Q15149
B	Plectin	protein	229	86% helix, 0% strand	Q15149

Ligands and binding sites

1PE · Pentaethylene glycol · additive · 2 copies · chains A, B
EDO · 1,2-ethanediol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	623	0.72	0.80	60	empty
2	308	0.52	0.74	33	empty

Interfaces

1 interface between chains.

A–B · 617 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

5J1G · Structure of the spectrin repeats 7 and 8 of the plakin domain of plectin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15149
Elsewhere: RCSB PDB 5J1G · PDBe 5J1G · UniProt Q15149

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