MolNFT v1 · #12283 · protein

Crystal structure of antibody PC287 in complex with PS1 peptide

1KC5 · PC287 immunoglobulin: “Crystal structure of antibody PC287 in complex with PS1 peptide”. X-ray diffraction, 2 pockets (best druggability 0.53). MolNFT v1 #12283 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1KC5
Type: protein
Length: 439 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: PC287 immunoglobulin; PS1 peptide
UniProt: Q8VC55, P01869
Pockets: 2 · best druggability 0.53

Structure

x-ray diffraction · 3 distinct chains · 4% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	PC287 immunoglobulin	protein	214	5% helix, 48% strand	Q8VC55
H	PC287 immunoglobulin	protein	217	3% helix, 53% strand	P01869
P	PS1 peptide	protein	8	0% helix, 0% strand	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	308	0.53	0.74	48	empty
2	66	0.30	0.74	13	empty

Interfaces

3 interfaces between chains.

L–H · 1963 Å² buried · 15 hydrogen bonds · protein-protein
H–P · 331 Å² buried · 6 hydrogen bonds · protein-protein
L–P · 231 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

1KC5 · Crystal structure of antibody PC287 in complex with PS1 peptide · the same entry in another collection · chain L against L, TM-score 1.00
P01869 · AlphaFold monomer V2.0 prediction for ig gamma-1 chain C region, membrane-bound form… · a predicted model of the same protein · chain H against A, TM-score 0.51

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8VC55
Every structure of UniProt P01869
Elsewhere: RCSB PDB 1KC5 · PDBe 1KC5 · UniProt Q8VC55 · UniProt P01869

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.