MolNFT v1 · #122824 · protein
Structure of human TSLP:TSLPR in complex with mouse il-7RALPHA
5J12 · Thymic stromal lymphopoietin: “Structure of human TSLP:TSLPR in complex with mouse il-7RALPHA”. X-ray diffraction, 2 ligands (NAG, SO4), 5 pockets (best druggability 0.68). MolNFT v1 #122824 on GenesisL1: 3D structure, binding sites…
- PDB
- 5J12
- Type
- protein
- Length
- 510 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Thymic stromal lymphopoietin; Interleukin-7 receptor subunit alpha; Cytokine…
- UniProt
- Q969D9, P16872, Q9HC73
- Ligands
- NAG, SO4
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thymic stromal lymphopoietin | protein | 127 | 54% helix, 1% strand | Q969D9 |
| B | Interleukin-7 receptor subunit alpha | protein | 194 | 5% helix, 51% strand | P16872 |
| C | Cytokine receptor-like factor 2 | protein | 189 | 7% helix, 51% strand | Q9HC73 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A, C
- SO4 · Sulfate ion · ion · 3 copies · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 731 | 0.68 | 0.76 | 92 | empty |
| 2 | 305 | 0.63 | 0.80 | 38 | empty |
| 3 | 50 | 0.59 | 0.92 | 16 | empty |
| 4 | 63 | 0.29 | 0.74 | 15 | empty |
| 5 | 60 | 0.29 | 0.74 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1019 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 550 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 68 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 disulfide, 3 glycan (disulfide, N-glycosylation).
Compared structures
- 5J12 · Structure of human TSLP:TSLPR in complex with mouse IL-7Ralpha · the same entry in another collection · chain A against A, TM-score 1.00
- P16872 · AlphaFold monomer V2.0 prediction for interleukin-7 receptor subunit alpha (P16872) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q9HC73 · AlphaFold monomer V2.0 prediction for cytokine receptor-like factor 2 (Q9HC73) · a predicted model of the same protein · chain C against A, TM-score 0.98
- Q969D9 · AlphaFold monomer V2.0 prediction for thymic stromal lymphopoietin (Q969D9) · a predicted model of the same protein · chain A against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q969D9
- Every structure of UniProt P16872
- Every structure of UniProt Q9HC73
- Elsewhere: RCSB PDB 5J12 · PDBe 5J12 · UniProt Q969D9 · UniProt P16872 · UniProt Q9HC73
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.