MolNFT v1 · #122823 · protein
Structure of human tslp in complex with tslpr and il-7RALPHA
5J11 · Thymic stromal lymphopoietin: “Structure of human tslp in complex with tslpr and il-7RALPHA”. X-ray diffraction, 1 ligand (NAG), 5 pockets (best druggability 0.60). MolNFT v1 #122823 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5J11
- Type
- protein
- Length
- 500 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Thymic stromal lymphopoietin; Interleukin-7 receptor subunit alpha; Cytokine…
- UniProt
- Q969D9, D6RGV2, Q9HC73
- Ligands
- NAG
- Pockets
- 5 · best druggability 0.60
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thymic stromal lymphopoietin | protein | 114 | 59% helix, 0% strand | Q969D9 |
| B | Interleukin-7 receptor subunit alpha | protein | 196 | 5% helix, 52% strand | D6RGV2 |
| C | Cytokine receptor-like factor 2 | protein | 190 | 6% helix, 50% strand | Q9HC73 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains C
- PGE · Triethylene glycol · additive · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 356 | 0.60 | 0.77 | 51 | empty |
| 2 | 284 | 0.59 | 0.78 | 38 | empty |
| 3 | 77 | 0.42 | 0.80 | 14 | empty |
| 4 | 64 | 0.37 | 0.79 | 14 | empty |
| 5 | 90 | 0.36 | 0.75 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1010 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 649 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 449 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 5J11 · Structure of human TSLP in complex with TSLPR and IL-7Ralpha · the same entry in another collection · chain A against A, TM-score 1.00
- Q9HC73 · AlphaFold monomer V2.0 prediction for cytokine receptor-like factor 2 (Q9HC73) · a predicted model of the same protein · chain C against A, TM-score 0.99
- Q969D9 · AlphaFold monomer V2.0 prediction for thymic stromal lymphopoietin (Q969D9) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q969D9
- Every structure of UniProt D6RGV2
- Every structure of UniProt Q9HC73
- Elsewhere: RCSB PDB 5J11 · PDBe 5J11 · UniProt Q969D9 · UniProt D6RGV2 · UniProt Q9HC73
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