MolNFT v1 · #122806 · protein

De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity

5J0J · Designed protein 2L6HC3_6: “De novo design of protein homo-oligomers with modular hydrogen bond network-mediated specificity”. X-ray diffraction, 1 pocket (best druggability 0.29). MolNFT v1 #122806 on GenesisL1: 3D structure…

PDB: 5J0J
Type: protein
Length: 210 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Designed protein 2L6HC3_6
Pockets: 1 · best druggability 0.29

Structure

x-ray diffraction · 3 distinct chains · 88% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Designed protein 2L6HC3_6	protein	70	83% helix, 0% strand	—
B	Designed protein 2L6HC3_6	protein	69	90% helix, 0% strand	—
C	Designed protein 2L6HC3_6	protein	71	92% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.29	0.75	11	empty

Interfaces

3 interfaces between chains.

A–C · 1074 Å² buried · 7 hydrogen bonds · protein-protein
A–B · 989 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 948 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

5J0J · De novo design of protein homo-oligomers with modular hydrogen bond network-mediated… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5J0J · PDBe 5J0J

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.