MolNFT v1 · #122772 · protein

Lassa virus L protein cap-snatching endonuclease. apo form

5IZH · RNA-directed RNA polymerase L: “Lassa virus L protein cap-snatching endonuclease. apo form”. X-ray diffraction, 3 pockets (best druggability 0.59). MolNFT v1 #122772 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5IZH
Type: protein
Length: 342 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-directed RNA polymerase L
EC: 2.7.7.48
UniProt: Q6GWS6
Pockets: 3 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 56% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	RNA-directed RNA polymerase L (EC 2.7.7.48)	protein	171	56% helix, 15% strand	Q6GWS6

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	351	0.59	0.77	34	empty
2	96	0.33	0.73	18	empty
3	59	0.29	0.75	18	empty

Interfaces

1 interface between chains.

A–B · 565 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

5IZH · Lassa virus L protein cap-snatching endonuclease. apo form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6GWS6
Elsewhere: RCSB PDB 5IZH · PDBe 5IZH · UniProt Q6GWS6

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.