MolNFT v1 · #122687 · protein

Crystal structure of the transporter malt, the eiic domain from the maltose-specific phosphotransferase system

5IWS · Protein-N(PI)-phosphohistidine-sugar phosphotransferase…: “Crystal structure of the transporter malt, the eiic domain from the maltose-specific phosphotransferase system”. X-ray diffraction, 1 ligand (GLC), 4 pockets (best…

PDB: 5IWS
Type: protein
Length: 443 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the…
EC: 2.7.1.69
UniProt: Q63GK8
Ligands: GLC
Pockets: 4 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 69% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system) (pts system glucose- specific iibc component) (EC 2.7.1.69)	protein	443	69% helix, 5% strand	Q63GK8

Ligands and binding sites

GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	296	0.84	0.94	35	GLC
2	403	0.61	0.76	42	empty
3	145	0.43	0.75	20	empty
4	97	0.38	0.75	20	empty

Modifications

Observed in the structure: 16 modified (engineered).

Compared structures

5IWS · Crystal structure of the transporter MalT, the EIIC domain from the maltose-specific… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q63GK8
Elsewhere: RCSB PDB 5IWS · PDBe 5IWS · UniProt Q63GK8

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