MolNFT v1 · #122580 · protein + DNA

Tia-1 RRM2 recognition of target oligonucleotide

5ITH · Nucleolysin tia-1 isoform P40: “Tia-1 RRM2 recognition of target oligonucleotide”. X-ray diffraction. MolNFT v1 #122580 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5ITH
Type: protein + DNA
Length: 83 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleolysin tia-1 isoform P40; DNA (5'-D(*AP*CP*TP*CP*C*TP*TP*TP*TP*T)-3')
UniProt: P31483

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleolysin tia-1 isoform P40	protein	80	28% helix, 39% strand	P31483
B	DNA (5'-D(APCPTPCPCTPTPTPTPT)-3')	dna	3	—	—

Interfaces

1 interface between chains.

A–B · 442 Å² buried · 7 hydrogen bonds · protein-nucleic

Compared structures

5ITH · TIA-1 RRM2 recognition of target oligonucleotide · the same entry in another collection · chain A against A, TM-score 1.00
P31483 · AlphaFold monomer V2.0 prediction for nucleolysin tia-1 isoform P40 (P31483) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31483
Elsewhere: RCSB PDB 5ITH · PDBe 5ITH · UniProt P31483

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