MolNFT v1 · #122574 · protein
Crystal structure of the anti-rsv F Fab 14N4
5ITB · Anti-rsv F Fab 14N4 heavy chain: “Crystal structure of the anti-rsv F Fab 14N4”. X-ray diffraction, 4 pockets (best druggability 0.63). MolNFT v1 #122574 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ITB
- Type
- protein
- Length
- 435 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti-rsv F Fab 14N4 heavy chain; Anti-rsv F Fab 14N4 light chain
- Pockets
- 4 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Anti-rsv F Fab 14N4 heavy chain | protein | 220 | 10% helix, 47% strand | — |
| L | Anti-rsv F Fab 14N4 light chain | protein | 215 | 5% helix, 50% strand | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 568 | 0.63 | 0.75 | 59 | empty |
| 2 | 58 | 0.46 | 0.84 | 21 | empty |
| 3 | 96 | 0.45 | 0.80 | 26 | empty |
| 4 | 100 | 0.36 | 0.74 | 25 | empty |
Interfaces
1 interface between chains.
- H–L · 2099 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 5ITB · Crystal structure of the anti-RSV F Fab 14N4 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5ITB · PDBe 5ITB
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