MolNFT v1 · #122560 · protein
Crystal structure of the ribosomal-protein-S18-alanine N- acetyltransferase from escherichia COLI
5ISV · Ribosomal-protein-alanine acetyltransferase: “Crystal structure of the ribosomal-protein-S18-alanine N- acetyltransferase from escherichia COLI”. X-ray diffraction, 3 pockets (best druggability 0.62). MolNFT v1 #122560 on GenesisL1…
- PDB
- 5ISV
- Type
- protein
- Length
- 311 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribosomal-protein-alanine acetyltransferase
- EC
- 2.3.1.128
- UniProt
- P0A946
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128) | protein | 156 | 30% helix, 38% strand | P0A946 |
| B | Ribosomal-protein-alanine acetyltransferase (EC 2.3.1.128) | protein | 155 | 30% helix, 38% strand | P0A946 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 429 | 0.62 | 0.76 | 37 | empty |
| 2 | 136 | 0.54 | 0.81 | 26 | empty |
| 3 | 141 | 0.40 | 0.74 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1346 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 5ISV · Crystal structure of the ribosomal-protein-S18-alanine N-acetyltransferase from… · the same entry in another collection · chain A against A, TM-score 1.00
- P0A946 · AlphaFold monomer V2.0 prediction for [ribosomal protein S18]-alanine N-acetyltransferase… · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A946
- Elsewhere: RCSB PDB 5ISV · PDBe 5ISV · UniProt P0A946
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