MolNFT v1 · #122515 · protein

Structure of the mouse sad-B ais-KA1 fragment

5IRI · SERINE/THREONINE-protein kinase BRSK1: “Structure of the mouse sad-B ais-KA1 fragment”. X-ray diffraction, 3 pockets (best druggability 0.62). MolNFT v1 #122515 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5IRI
Type: protein
Length: 210 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase BRSK1
EC: 2.7.11.26
UniProt: Q5RJI5
Pockets: 3 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	SERINE/THREONINE-protein kinase BRSK1 (EC 2.7.11.26)	protein	105	31% helix, 40% strand	Q5RJI5

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	127	0.62	0.86	18	empty
2	78	0.40	0.78	23	empty
3	54	0.24	0.72	18	empty

Interfaces

1 interface between chains.

A–B · 681 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

5IRI · Structure of the mouse SAD-B AIS-KA1 fragment · the same entry in another collection · chain A against A, TM-score 1.00
Q5RJI5 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase BRSK1 (Q5RJI5) · a predicted model of the same protein · chain B against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5RJI5
Elsewhere: RCSB PDB 5IRI · PDBe 5IRI · UniProt Q5RJI5

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