MolNFT v1 · #122281 · protein
Crystal structure of the C-terminal domain of the MIT1 nucleosome remodeler in complex with CLR1
5IKF · Chromatin remodeling factor MIT1: “Crystal structure of the C-terminal domain of the MIT1 nucleosome remodeler in complex with CLR1”. X-ray diffraction, 2 ligands (ZN, CL), 3 pockets (best druggability 0.47). MolNFT v1 #122281 on…
- PDB
- 5IKF
- Type
- protein
- Length
- 285 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromatin remodeling factor MIT1; Cryptic loci regulator protein 1
- EC
- 3.6.4.-
- UniProt
- Q9P793, O74808
- Ligands
- ZN, CL
- Pockets
- 3 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromatin remodeling factor MIT1 (EC 3.6.4.-) | protein | 150 | 40% helix, 7% strand | Q9P793 |
| B | Cryptic loci regulator protein 1 | protein | 135 | 50% helix, 6% strand | O74808 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.47 | 0.82 | 22 | empty |
| 2 | 111 | 0.38 | 0.74 | 17 | empty |
| 3 | 69 | 0.32 | 0.75 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 3073 Ų buried · 50 hydrogen bonds · protein-protein
Compared structures
- 5IKF · Crystal structure of the C-terminal domain of the Mit1 nucleosome remodeler in complex… · the same entry in another collection · chain A against A, TM-score 1.00
- O74808 · AlphaFold monomer V2.0 prediction for cryptic loci regulator protein 1 (O74808) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q9P793 · AlphaFold monomer V2.0 prediction for chromatin remodeling factor MIT1 (Q9P793) · a predicted model of the same protein · chain A against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9P793
- Every structure of UniProt O74808
- Elsewhere: RCSB PDB 5IKF · PDBe 5IKF · UniProt Q9P793 · UniProt O74808
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