MolNFT v1 · #122255 · protein
Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of NUP188, 16 copies of NUP205)
5IJO · Nuclear pore complex protein NUP155: “Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of NUP188, 16…”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #122255 on…
- PDB
- 5IJO
- Type
- protein
- Length
- 15,444 residues
- Chains
- 26
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear pore complex protein NUP155; Nuclear pore complex protein NUP93; Nuclear pore…
- UniProt
- O75694, Q8N1F7, Q92621, Q7Z3B4, Q9BVL2, P37198, Q5SRE5
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 8 distinct chains · 58% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Nuclear pore complex protein NUP155 | protein | 650 | 30% helix, 26% strand | O75694 |
| C, I, O, U | Nuclear pore complex protein NUP93 | protein | 636 | 58% helix, 1% strand | Q8N1F7 |
| D, P | Nuclear pore complex protein NUP205 | protein | 1028 | 73% helix, 0% strand | Q92621 |
| E, K, Q, W | Nuclear pore complex protein NUP155 | protein | 1083 | 46% helix, 16% strand | O75694 |
| F, L, R, X | Nucleoporin P54 | protein | 335 | 62% helix, 12% strand | Q7Z3B4 |
| G, M, S, Y | Nucleoporin P58/P45 | protein | 171 | 86% helix, 0% strand | Q9BVL2 |
| H, N, T, Z | Nuclear pore glycoprotein P62 | protein | 169 | 85% helix, 0% strand | P37198 |
| J, V | Nucleoporin NUP188 homolog | protein | 1256 | 64% helix, 2% strand | Q5SRE5 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1193 | 0.83 | 0.84 | 130 | empty |
| 2 | 1182 | 0.83 | 0.84 | 129 | empty |
| 3 | 705 | 0.82 | 0.86 | 125 | empty |
| 4 | 1001 | 0.82 | 0.84 | 149 | empty |
| 5 | 955 | 0.82 | 0.84 | 144 | empty |
Interfaces
35 interfaces between chains.
- C–D · 860 Ų buried · 27 hydrogen bonds · protein-protein
- L–N · 784 Ų buried · 0 hydrogen bonds · protein-protein
- F–H · 784 Ų buried · 0 hydrogen bonds · protein-protein
- X–Z · 784 Ų buried · 0 hydrogen bonds · protein-protein
- R–T · 780 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5IJO · Alternative composite structure of the inner ring of the human nuclear pore complex (16… · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75694
- Every structure of UniProt Q8N1F7
- Every structure of UniProt Q92621
- Every structure of UniProt Q7Z3B4
- Every structure of UniProt Q9BVL2
- Every structure of UniProt P37198
- Every structure of UniProt Q5SRE5
- Elsewhere: RCSB PDB 5IJO · PDBe 5IJO · UniProt O75694 · UniProt Q8N1F7 · UniProt Q92621 · UniProt Q7Z3B4 · UniProt Q9BVL2 · UniProt P37198 · UniProt Q5SRE5
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