MolNFT v1 · #122228 · protein
Crystal structure of equine serum albumin in the presence of 15 mm zinc at pH 6.5
5IIX: “Crystal structure of equine serum albumin in the presence of 15 mm zinc at pH 6.5”. X-ray diffraction, 3 ligands (UNL, ZN, SO4), 8 pockets (best druggability 0.80). MolNFT v1 #122228 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5IIX
- Type
- protein
- Length
- 577 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serum albumin
- UniProt
- P35747
- Ligands
- UNL, ZN, SO4
- Pockets
- 8 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serum albumin | protein | 577 | 73% helix, 0% strand | P35747 |
Ligands and binding sites
- UNL · Unknown ligand · ligand · 2 copies · chains A
- ZN · Zinc ion · metal · 11 copies · chains A
- SO4 · Sulfate ion · ion · 6 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 503 | 0.80 | 0.87 | 62 | ZN, SO4 |
| 2 | 836 | 0.77 | 0.80 | 64 | ZN |
| 3 | 70 | 0.66 | 0.93 | 24 | UNL |
| 4 | 201 | 0.59 | 0.81 | 21 | empty |
| 5 | 223 | 0.53 | 0.76 | 27 | empty |
Modifications
Observed in the structure: 17 disulfide (disulfide).
Compared structures
- 5IIX · Crystal structure of Equine Serum Albumin in the presence of 15 mM zinc at pH 6.5 · the same entry in another collection · chain A against A, TM-score 1.00
- P35747 · AlphaFold monomer V2.0 prediction for albumin (P35747) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35747
- Elsewhere: RCSB PDB 5IIX · PDBe 5IIX · UniProt P35747
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