MolNFT v1 · #122132 · protein
Crystal structure of N. vectensis camkii-B hub at pH 4.2
5IG5: “Crystal structure of N. vectensis camkii-B hub at pH 4.2”. X-ray diffraction, 16 pockets (best druggability 0.76). MolNFT v1 #122132 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5IG5
- Type
- protein
- Length
- 968 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Camkii-B hub
- UniProt
- A7RF52
- Pockets
- 16 · best druggability 0.76
Structure
x-ray diffraction · 6 distinct chains · 26% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Camkii-B hub | protein | 137 | 26% helix, 47% strand | A7RF52 |
| F | Camkii-B hub | protein | 143 | 26% helix, 47% strand | A7RF52 |
| C | Camkii-B hub | protein | 137 | 26% helix, 48% strand | A7RF52 |
| D | Camkii-B hub | protein | 136 | 26% helix, 48% strand | A7RF52 |
| E | Camkii-B hub | protein | 139 | 25% helix, 49% strand | A7RF52 |
| B, G | Camkii-B hub | protein | 138 | 26% helix, 48% strand | A7RF52 |
Pockets
16 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 108 | 0.76 | 0.96 | 22 | empty |
| 2 | 159 | 0.75 | 0.93 | 32 | empty |
| 3 | 516 | 0.69 | 0.79 | 37 | empty |
| 4 | 514 | 0.69 | 0.79 | 35 | empty |
| 5 | 551 | 0.67 | 0.78 | 40 | empty |
Interfaces
13 interfaces between chains.
- F–E · 1285 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 1236 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 1145 Ų buried · 19 hydrogen bonds · protein-protein
- B–G · 732 Ų buried · 8 hydrogen bonds · protein-protein
- C–E · 711 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 5IG5 · Crystal structure of N. vectensis CaMKII-B hub at pH 4.2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A7RF52
- Elsewhere: RCSB PDB 5IG5 · PDBe 5IG5 · UniProt A7RF52
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.