MolNFT v1 · #122111 · protein

Crystal structure of the BCR Fab fragment from subset #2 case P11475

5IFH · Heavy chain of the Fab fragment from BCR derived from the…: “Crystal structure of the BCR Fab fragment from subset #2 case P11475”. X-ray diffraction, 2 pockets (best druggability 0.54). MolNFT v1 #122111 on GenesisL1: 3D structure…

PDB: 5IFH
Type: protein
Length: 389 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heavy chain of the Fab fragment from BCR derived from the P11475 cll clone; Light chain…
Pockets: 2 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Heavy chain of the Fab fragment from BCR derived from the P11475 cll clone	protein	178	3% helix, 51% strand	—
L	Light chain of the Fab fragment from BCR derived from the P11475 cll clone	protein	211	8% helix, 47% strand	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	360	0.54	0.74	56	empty
2	79	0.31	0.73	11	empty

Interfaces

1 interface between chains.

H–L · 1744 Å² buried · 20 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5IFH · Crystal structure of the BCR Fab fragment from subset #2 case P11475 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5IFH · PDBe 5IFH

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