MolNFT v1 · #122105 · protein

Crystal structure of polymerase acid protein (pa) from influenza a virus, wilson-SMITH/1933 (H1N1) bound to follow on fragment ebsi-4719 5-chloro-2-(1H-imidazol-1-YL)ANILINE

5IFB · Polymerase acidic protein: “Crystal structure of polymerase acid protein (pa) from influenza a virus, wilson-SMITH/1933 (H1N1) bound to…”. X-ray diffraction, 2 ligands (6AV, CL), 6 pockets (best druggability 0.63). MolNFT v1 #122105…

PDB: 5IFB
Type: protein
Length: 404 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polymerase acidic protein
UniProt: P15659
Ligands: 6AV, CL
Pockets: 6 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polymerase acidic protein	protein	404	44% helix, 20% strand	P15659

Ligands and binding sites

6AV · 5-chloro-2-(1H-imidazol-1-yl)aniline · ligand · chains A
CL · Chloride ion · ion · chains A
DMS · Dimethyl sulfoxide · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	212	0.63	0.82	32	DMS
2	70	0.44	0.81	14	6AV
3	105	0.41	0.77	25	empty
4	98	0.35	0.74	24	empty
5	60	0.32	0.76	14	empty

Compared structures

5IFB · Crystal structure of polymerase acid protein (PA) from Influenza A virus… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15659
Elsewhere: RCSB PDB 5IFB · PDBe 5IFB · UniProt P15659

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