MolNFT v1 · #122088 · protein
Crystal structure of mycobacterium tuberculosis ATP-independent proteasome activator tetramer
5IEU · Bacterial proteasome activator: “Crystal structure of mycobacterium tuberculosis ATP-independent proteasome activator tetramer”. X-ray diffraction, 3 pockets (best druggability 0.46). MolNFT v1 #122088 on GenesisL1: 3D structure…
- PDB
- 5IEU
- Type
- protein
- Length
- 194 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bacterial proteasome activator
- UniProt
- A0A0K2KYP6
- Pockets
- 3 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bacterial proteasome activator | protein | 99 | 72% helix, 0% strand | A0A0K2KYP6 |
| B | Bacterial proteasome activator | protein | 95 | 69% helix, 0% strand | A0A0K2KYP6 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 95 | 0.46 | 0.80 | 22 | empty |
| 2 | 92 | 0.41 | 0.78 | 19 | empty |
| 3 | 67 | 0.35 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1235 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 5IEU · Crystal Structure of Mycobacterium Tuberculosis ATP-independent Proteasome Activator… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0K2KYP6
- Elsewhere: RCSB PDB 5IEU · PDBe 5IEU · UniProt A0A0K2KYP6
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