MolNFT v1 · #122027 · protein
Solution structure of the pore-forming region of C. elegans mitochondrial calcium uniporter (mcu)
5ID3: “Solution structure of the pore-forming region of C. elegans mitochondrial calcium uniporter (mcu)”. Solution nmr, 18 pockets (best druggability 0.85). MolNFT v1 #122027 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ID3
- Type
- protein
- Length
- 765 residues
- Chains
- 5
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial calcium uniporter
- UniProt
- Q21121
- Pockets
- 18 · best druggability 0.85
Structure
solution nmr · 1 distinct chain · 58% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Mitochondrial calcium uniporter | protein | 153 | 58% helix, 0% strand | Q21121 |
Pockets
18 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 523 | 0.85 | 0.91 | 45 | empty |
| 2 | 731 | 0.85 | 0.87 | 59 | empty |
| 3 | 995 | 0.78 | 0.79 | 90 | empty |
| 4 | 878 | 0.77 | 0.80 | 65 | empty |
| 5 | 167 | 0.76 | 0.93 | 23 | empty |
Interfaces
10 interfaces between chains.
- A–B · 2098 Ų buried · 19 hydrogen bonds · protein-protein
- D–E · 2001 Ų buried · 13 hydrogen bonds · protein-protein
- A–E · 1945 Ų buried · 17 hydrogen bonds · protein-protein
- B–C · 1908 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1902 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 5ID3 · Solution structure of the pore-forming region of C. elegans Mitochondrial Calcium… · the same entry in another collection · chain D against D, TM-score 1.00
- Q21121 · AlphaFold monomer V2.0 prediction for calcium uniporter protein, mitochondrial (Q21121) · a predicted model of the same protein · chain A against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q21121
- Elsewhere: RCSB PDB 5ID3 · PDBe 5ID3 · UniProt Q21121
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