MolNFT v1 · #121988 · protein

Complex of mlcc bound to the tandem iq motif of myoc

5IBW · Calcium-binding ef-hand domain-containing protein: “Complex of mlcc bound to the tandem iq motif of myoc”. X-ray diffraction, 1 ligand (NA), 1 pocket (best druggability 0.39). MolNFT v1 #121988 on GenesisL1: 3D structure, binding…

PDB: 5IBW
Type: protein
Length: 192 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calcium-binding ef-hand domain-containing protein; Myosin ic heavy chain
UniProt: Q54HC2, P42522
Ligands: NA
Pockets: 1 · best druggability 0.39

Structure

x-ray diffraction · 3 distinct chains · 61% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calcium-binding ef-hand domain-containing protein	protein	76	53% helix, 5% strand	Q54HC2
B	Calcium-binding ef-hand domain-containing protein	protein	73	53% helix, 5% strand	Q54HC2
C	Myosin ic heavy chain	protein	43	91% helix, 0% strand	P42522

Ligands and binding sites

NA · Sodium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	115	0.39	0.75	23	empty

Interfaces

3 interfaces between chains.

A–C · 1239 Å² buried · 15 hydrogen bonds · protein-protein
B–C · 1166 Å² buried · 25 hydrogen bonds · protein-protein
A–B · 166 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5IBW · Complex of MlcC bound to the tandem IQ motif of MyoC · the same entry in another collection · chain A against A, TM-score 1.00
P42522 · AlphaFold monomer V2.0 prediction for myosin ic heavy chain (P42522) · a predicted model of the same protein · chain C against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q54HC2
Every structure of UniProt P42522
Elsewhere: RCSB PDB 5IBW · PDBe 5IBW · UniProt Q54HC2 · UniProt P42522

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