MolNFT v1 · #121814 · protein
Crystal structure of a dbccp-variant of chaetomium thermophilum acetyl-CoA carboxylase
5I6I · Acetyl-CoA carboxylase-like PROTEIN,ACETYL-CoA carboxylase…: “Crystal structure of a dbccp-variant of chaetomium thermophilum acetyl-CoA carboxylase”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #121814 on…
- PDB
- 5I6I
- Type
- protein
- Length
- 2,793 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acetyl-CoA carboxylase-like PROTEIN,ACETYL-CoA carboxylase- like PROTEIN,ACETYL-CoA…
- EC
- 6.4.1.2
- UniProt
- G0S3L5
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acetyl-CoA carboxylase-like PROTEIN,ACETYL-CoA carboxylase- like PROTEIN,ACETYL-CoA carboxylase-like protein (EC 6.4.1.2) | protein | 1399 | 42% helix, 15% strand | G0S3L5 |
| B | Acetyl-CoA carboxylase-like PROTEIN,ACETYL-CoA carboxylase- like PROTEIN,ACETYL-CoA carboxylase-like protein (EC 6.4.1.2) | protein | 1394 | 41% helix, 16% strand | G0S3L5 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1067 | 0.84 | 0.85 | 94 | empty |
| 2 | 361 | 0.82 | 0.91 | 46 | empty |
| 3 | 160 | 0.79 | 0.95 | 31 | empty |
| 4 | 340 | 0.79 | 0.89 | 51 | empty |
| 5 | 95 | 0.75 | 0.96 | 30 | empty |
Interfaces
1 interface between chains.
- A–B · 6890 Ų buried · 51 hydrogen bonds · protein-protein
Compared structures
- 5I6I · Crystal structure of a dBCCP-variant of Chaetomium thermophilum acetyl-CoA carboxylase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S3L5
- Elsewhere: RCSB PDB 5I6I · PDBe 5I6I · UniProt G0S3L5
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