MolNFT v1 · #121799 · protein

Crystal structure of the RNA-dependent RNA polymerase of a human picorbirnavirus

5I61 · Potential RNA-dependent RNA polymerase: “Crystal structure of the RNA-dependent RNA polymerase of a human picorbirnavirus”. X-ray diffraction, 7 pockets (best druggability 0.82). MolNFT v1 #121799 on GenesisL1: 3D structure, binding…

PDB: 5I61
Type: protein
Length: 1,033 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Potential RNA-dependent RNA polymerase
EC: 2.7.7.48
UniProt: Q50LE4
Pockets: 7 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 47% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Potential RNA-dependent RNA polymerase (EC 2.7.7.48)	protein	510	46% helix, 14% strand	Q50LE4
A	Potential RNA-dependent RNA polymerase (EC 2.7.7.48)	protein	523	48% helix, 15% strand	Q50LE4

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1134	0.82	0.83	90	empty
2	782	0.68	0.75	69	empty
3	431	0.65	0.78	47	empty
4	437	0.58	0.74	46	empty
5	251	0.55	0.77	31	empty

Interfaces

1 interface between chains.

B–A · 474 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 36 modified (engineered).

Compared structures

5I61 · Crystal structure of the RNA-dependent RNA polymerase of a human picorbirnavirus · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q50LE4
Elsewhere: RCSB PDB 5I61 · PDBe 5I61 · UniProt Q50LE4

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