MolNFT v1 · #121777 · protein

Salmonella global domain 191

5I5F · Inner membrane protein yejm: “Salmonella global domain 191”. X-ray diffraction, 18 pockets (best druggability 0.69). MolNFT v1 #121777 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5I5F
Type: protein
Length: 1,356 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inner membrane protein yejm
UniProt: P40709
Pockets: 18 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Inner membrane protein yejm	protein	339	35% helix, 20% strand	P40709

Pockets

18 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	722	0.69	0.76	67	empty
2	484	0.67	0.79	48	empty
3	498	0.60	0.74	54	empty
4	343	0.57	0.76	34	empty
5	300	0.54	0.75	31	empty

Interfaces

4 interfaces between chains.

C–D · 480 Å² buried · 8 hydrogen bonds · protein-protein
A–C · 422 Å² buried · 6 hydrogen bonds · protein-protein
B–D · 407 Å² buried · 8 hydrogen bonds · protein-protein
A–B · 231 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

5I5F · Salmonella global domain 191 · the same entry in another collection · chain A against A, TM-score 1.00
P40709 · AlphaFold monomer V2.0 prediction for inner membrane protein yejm (P40709) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P40709
Elsewhere: RCSB PDB 5I5F · PDBe 5I5F · UniProt P40709

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