MolNFT v1 · #121755 · protein

Immature hexagonal lattice of HIV-1 gag

5I4T · Ctd-SP1 fragment of HIV-1 gag: “Immature hexagonal lattice of HIV-1 gag”. X-ray diffraction, 2 pockets (best druggability 0.70). MolNFT v1 #121755 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5I4T
Type: protein
Length: 546 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ctd-SP1 fragment of HIV-1 gag
UniProt: Q699C3
Pockets: 2 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 67% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
G, H, I, J, K, L	Ctd-SP1 fragment of HIV-1 gag	protein	91	67% helix, 0% strand	Q699C3

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	767	0.70	0.76	93	empty
2	58	0.51	0.87	24	empty

Interfaces

6 interfaces between chains.

G–L · 684 Å² buried · 6 hydrogen bonds · protein-protein
H–I · 680 Å² buried · 4 hydrogen bonds · protein-protein
I–J · 677 Å² buried · 3 hydrogen bonds · protein-protein
G–H · 676 Å² buried · 3 hydrogen bonds · protein-protein
K–L · 675 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

5I4T · Immature hexagonal lattice of HIV-1 Gag · the same entry in another collection · chain G against G, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q699C3
Elsewhere: RCSB PDB 5I4T · PDBe 5I4T · UniProt Q699C3

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