MolNFT v1 · #121690 · protein

Domain characterization of the wd protein PWP2 and their relevance in ribosome biogenesis

5I2T · Periodic tryptophan protein 2: “Domain characterization of the wd protein PWP2 and their relevance in ribosome biogenesis”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.81). MolNFT v1 #121690 on GenesisL1: 3D…

PDB: 5I2T
Type: protein
Length: 606 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Periodic tryptophan protein 2
UniProt: P25635
Ligands: SO4
Pockets: 4 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Periodic tryptophan protein 2	protein	606	0% helix, 51% strand	P25635

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	864	0.81	0.83	63	empty
2	640	0.77	0.83	57	empty
3	134	0.59	0.84	29	empty
4	82	0.33	0.74	15	empty

Compared structures

5I2T · Domain characterization of the WD protein Pwp2 and their relevance in ribosome biogenesis · the same entry in another collection · chain A against A, TM-score 1.00
P25635 · AlphaFold monomer V2.0 prediction for periodic tryptophan protein 2 (P25635) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25635
Elsewhere: RCSB PDB 5I2T · PDBe 5I2T · UniProt P25635

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