MolNFT v1 · #121616 · protein
Structure of human C4B-binding protein alpha chain ccp domains 1 and 2 in complex with the hypervariable region of mutant group a streptococcus M2 (K65A, N66A) protein
5I0Q · M protein, serotype 2.1: “Structure of human C4B-binding protein alpha chain ccp domains 1 and 2 in complex with the hypervariable…”. X-ray diffraction, 2 pockets (best druggability 0.35). MolNFT v1 #121616 on GenesisL1: 3D…
- PDB
- 5I0Q
- Type
- protein
- Length
- 159 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- M protein, serotype 2.1; C4B-binding protein alpha chain
- UniProt
- P50468, P04003
- Pockets
- 2 · best druggability 0.35
Structure
x-ray diffraction · 2 distinct chains · 16% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | M protein, serotype 2.1 | protein | 34 | 74% helix, 0% strand | P50468 |
| B | C4B-binding protein alpha chain | protein | 125 | 0% helix, 42% strand | P04003 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.35 | 0.75 | 19 | empty |
| 2 | 65 | 0.28 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 672 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5I0Q · Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P04003 · AlphaFold monomer V2.0 prediction for C4B-binding protein alpha chain (P04003) · a predicted model of the same protein · chain B against A, TM-score 0.90
- P50468 · AlphaFold monomer V2.0 prediction for M protein, serotype 2.1 (P50468) · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P50468
- Every structure of UniProt P04003
- Elsewhere: RCSB PDB 5I0Q · PDBe 5I0Q · UniProt P50468 · UniProt P04003
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.