MolNFT v1 · #1216 · protein

Structure of the C domain of synapsin ia from bovine brain

1AUV: “Structure of the C domain of synapsin ia from bovine brain”. X-ray diffraction, 4 pockets (best druggability 0.73). MolNFT v1 #1216 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1AUV
Type: protein
Length: 585 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Synapsin ia
UniProt: P17599
Pockets: 4 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Synapsin ia	protein	292	28% helix, 33% strand	P17599
B	Synapsin ia	protein	293	28% helix, 31% strand	P17599

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	471	0.73	0.82	72	empty
2	345	0.72	0.84	53	empty
3	130	0.39	0.74	23	empty
4	61	0.39	0.79	15	empty

Interfaces

1 interface between chains.

A–B · 513 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 20 modified (engineered).

Compared structures

1AUV · Structure of the C domain of synapsin ia from bovine brain · the same entry in another collection · chain A against A, TM-score 1.00
P17599 · AlphaFold monomer V2.0 prediction for synapsin-1 (P17599) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P17599
Elsewhere: RCSB PDB 1AUV · PDBe 1AUV · UniProt P17599

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