MolNFT v1 · #12156 · protein
Crystal structure of the human C-terminal CAP1-adenylyl cyclase associated protein
1K8F · Adenylyl cyclase-associated protein: “Crystal structure of the human C-terminal CAP1-adenylyl cyclase associated protein”. X-ray diffraction, 1 pocket (best druggability 0.56). MolNFT v1 #12156 on GenesisL1: 3D structure, binding…
- PDB
- 1K8F
- Type
- protein
- Length
- 628 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenylyl cyclase-associated protein
- UniProt
- Q01518
- Pockets
- 1 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 0% helix, 62% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Adenylyl cyclase-associated protein | protein | 157 | 0% helix, 62% strand | Q01518 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 430 | 0.56 | 0.74 | 44 | empty |
Interfaces
4 interfaces between chains.
- A–B · 1249 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1247 Ų buried · 13 hydrogen bonds · protein-protein
- A–D · 95 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 35 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 1K8F · Crystal structure of the human C-terminal CAP1-adenylyl cyclase associated protein · the same entry in another collection · chain D against D, TM-score 1.00
- Q01518 · AlphaFold monomer V2.0 prediction for adenylyl cyclase-associated protein 1 (Q01518) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q01518
- Elsewhere: RCSB PDB 1K8F · PDBe 1K8F · UniProt Q01518
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