MolNFT v1 · #121548 · protein
Structure of human C4B-binidng protein alpha chain ccp domains 1 and 2 in complex with the hypervariable region of group a streptococcus M22 protein
5HYT · Precursor to protein SIR22: “Structure of human C4B-binidng protein alpha chain ccp domains 1 and 2 in complex with the hypervariable…”. X-ray diffraction, 11 pockets (best druggability 0.53). MolNFT v1 #121548 on GenesisL1: 3D…
- PDB
- 5HYT
- Type
- protein
- Length
- 612 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Precursor to protein SIR22; C4B-binding protein alpha chain
- UniProt
- Q54901, P04003
- Pockets
- 11 · best druggability 0.53
Structure
x-ray diffraction · 4 distinct chains · 17% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, G | Precursor to protein SIR22 | protein | 29 | 86% helix, 0% strand | Q54901 |
| B, F | C4B-binding protein alpha chain | protein | 124 | 0% helix, 43% strand | P04003 |
| C, E | Precursor to protein SIR22 | protein | 28 | 93% helix, 0% strand | Q54901 |
| D, H | C4B-binding protein alpha chain | protein | 125 | 0% helix, 41% strand | P04003 |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 208 | 0.53 | 0.78 | 25 | empty |
| 2 | 103 | 0.52 | 0.82 | 19 | empty |
| 3 | 101 | 0.50 | 0.82 | 21 | empty |
| 4 | 146 | 0.43 | 0.75 | 27 | empty |
| 5 | 104 | 0.41 | 0.77 | 23 | empty |
Interfaces
12 interfaces between chains.
- G–E · 747 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 712 Ų buried · 7 hydrogen bonds · protein-protein
- F–E · 679 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 664 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 567 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 5HYT · Structure of human C4b-binidng protein alpha chain CCP domains 1 and 2 in complex with… · the same entry in another collection · chain E against E, TM-score 1.00
- P04003 · AlphaFold monomer V2.0 prediction for C4B-binding protein alpha chain (P04003) · a predicted model of the same protein · chain B against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q54901
- Every structure of UniProt P04003
- Elsewhere: RCSB PDB 5HYT · PDBe 5HYT · UniProt Q54901 · UniProt P04003
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