MolNFT v1 · #121467 · protein
Crystal structure of selenomethionine labelled gama glutamyl cyclotransferease specific to glutathione from yeast
5HWI · Glutathione-specific gamma-glutamylcyclotransferase: “Crystal structure of selenomethionine labelled gama glutamyl cyclotransferease specific to glutathione from…”. X-ray diffraction, 2 pockets (best druggability 0.64). MolNFT v1…
- PDB
- 5HWI
- Type
- protein
- Length
- 229 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutathione-specific gamma-glutamylcyclotransferase
- EC
- 2.3.2.-
- UniProt
- P32656
- Pockets
- 2 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutathione-specific gamma-glutamylcyclotransferase (EC 2.3.2.-) | protein | 229 | 35% helix, 28% strand | P32656 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 120 | 0.64 | 0.88 | 27 | SIN |
| 2 | 290 | 0.59 | 0.78 | 29 | empty |
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 5HWI · Crystal structure of selenomethionine labelled gama glutamyl cyclotransferease specific… · the same entry in another collection · chain A against A, TM-score 1.00
- P32656 · AlphaFold monomer V2.0 prediction for glutathione-specific gamma… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32656
- Elsewhere: RCSB PDB 5HWI · PDBe 5HWI · UniProt P32656
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