MolNFT v1 · #121368 · protein

Crystal structure of C-met kinase domain in complex with LXM108

5HTI · Hepatocyte growth factor receptor: “Crystal structure of C-met kinase domain in complex with LXM108”. X-ray diffraction, 1 ligand (66L), 1 pocket (best druggability 0.75). MolNFT v1 #121368 on GenesisL1: 3D structure, binding sites…

PDB: 5HTI
Type: protein
Length: 290 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hepatocyte growth factor receptor
EC: 2.7.10.1
UniProt: P08581
Ligands: 66L
Pockets: 1 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hepatocyte growth factor receptor (EC 2.7.10.1)	protein	290	41% helix, 17% strand	P08581

Ligands and binding sites

66L · N-[3-fluoro-4-({7-[2-(morpholin-4-yl)ethoxy]-1,6-naphthyridin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	468	0.75	0.83	53	66L

Compared structures

5HTI · Crystal structure of c-Met kinase domain in complex with LXM108 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08581
Elsewhere: RCSB PDB 5HTI · PDBe 5HTI · UniProt P08581

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