MolNFT v1 · #121275 · protein

WD40 domain of human E3 ubiquitin ligase COP1 (RFWD2)

5HQG · E3 ubiquitin-protein ligase RFWD2: “WD40 domain of human E3 ubiquitin ligase COP1 (RFWD2)”. X-ray diffraction, 1 pocket (best druggability 0.76). MolNFT v1 #121275 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5HQG
Type: protein
Length: 324 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: E3 ubiquitin-protein ligase RFWD2
EC: 6.3.2.-
UniProt: Q8NHY2
Pockets: 1 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 4% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	E3 ubiquitin-protein ligase RFWD2 (EC 6.3.2.-)	protein	324	4% helix, 48% strand	Q8NHY2

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	510	0.76	0.83	57	empty

Compared structures

5HQG · WD40 domain of Human E3 Ubiquitin Ligase COP1 (RFWD2) · the same entry in another collection · chain A against A, TM-score 1.00
Q8NHY2 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase COP1 (Q8NHY2) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8NHY2
Elsewhere: RCSB PDB 5HQG · PDBe 5HQG · UniProt Q8NHY2

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