MolNFT v1 · #121160 · protein

Crystal structure of interleukin-37

5HN1: “Crystal structure of interleukin-37”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.37). MolNFT v1 #121160 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5HN1
Type: protein
Length: 306 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-37
UniProt: Q9NZH6
Ligands: SO4
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interleukin-37	protein	157	10% helix, 44% strand	Q9NZH6
B	Interleukin-37	protein	149	8% helix, 44% strand	Q9NZH6

Ligands and binding sites

SO4 · Sulfate ion · ion · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.37	0.79	13	empty

Interfaces

1 interface between chains.

A–B · 535 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

5HN1 · Crystal structure of Interleukin-37 · the same entry in another collection · chain A against A, TM-score 1.00
Q9NZH6 · AlphaFold monomer V2.0 prediction for interleukin-37 (Q9NZH6) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NZH6
Elsewhere: RCSB PDB 5HN1 · PDBe 5HN1 · UniProt Q9NZH6

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.