MolNFT v1 · #121149 · protein

Myosin X motor activity

5HMO · Unconventional myosin-X: “Myosin X motor activity”. X-ray diffraction, 2 pockets (best druggability 0.42). MolNFT v1 #121149 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5HMO
Type: protein
Length: 253 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Unconventional myosin-X
UniProt: P79114
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 2 distinct chains · 85% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Unconventional myosin-X	protein	131	87% helix, 0% strand	P79114
C	Unconventional myosin-X	protein	122	83% helix, 0% strand	P79114

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	92	0.42	0.78	17	empty
2	53	0.27	0.74	13	empty

Interfaces

1 interface between chains.

A–C · 951 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

5HMO · myosin X motor activity · the same entry in another collection · chain A against A, TM-score 1.00
P79114 · AlphaFold monomer V2.0 prediction for unconventional myosin-X (P79114) · a predicted model of the same protein · chain C against A, TM-score 0.63

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P79114
Elsewhere: RCSB PDB 5HMO · PDBe 5HMO · UniProt P79114

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