MolNFT v1 · #121132 · protein

The intracellular domain of butyrophilin 3A1 protein

5HM7 · Butyrophilin subfamily 3 member A1: “The intracellular domain of butyrophilin 3A1 protein”. X-ray diffraction, 1 ligand (MG), 2 pockets (best druggability 0.63). MolNFT v1 #121132 on GenesisL1: 3D structure, binding sites and…

PDB: 5HM7
Type: protein
Length: 397 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Butyrophilin subfamily 3 member A1
UniProt: O00481
Ligands: MG
Pockets: 2 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 12% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Butyrophilin subfamily 3 member A1	protein	207	15% helix, 33% strand	O00481
B	Butyrophilin subfamily 3 member A1	protein	190	9% helix, 36% strand	O00481

Ligands and binding sites

MG · Magnesium ion · metal · 2 copies · chains A, B
BME · Beta-mercaptoethanol · additive · 4 copies · chains A, B
GOL · Glycerol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	312	0.63	0.80	38	BME, MG
2	274	0.57	0.77	27	GOL

Interfaces

1 interface between chains.

A–B · 511 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 covalent (additive adduct).

Compared structures

5HM7 · The Intracellular domain of Butyrophilin 3A1 protein · the same entry in another collection · chain A against A, TM-score 1.00
O00481 · AlphaFold monomer V2.0 prediction for butyrophilin subfamily 3 member A1 (O00481) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00481
Elsewhere: RCSB PDB 5HM7 · PDBe 5HM7 · UniProt O00481

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.