MolNFT v1 · #121084 · protein
Crystal structure of mouse TANKYRASE/HUMAN TRF1 complex
5HKP · Tankyrase-1: “Crystal structure of mouse TANKYRASE/HUMAN TRF1 complex”. X-ray diffraction, 2 pockets (best druggability 0.69). MolNFT v1 #121084 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5HKP
- Type
- protein
- Length
- 647 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tankyrase-1; Telomeric repeat-binding factor 1
- EC
- 2.4.2.30
- UniProt
- Q6PFX9, P54274
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 4 distinct chains · 51% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tankyrase-1 (EC 2.4.2.30) | protein | 313 | 52% helix, 0% strand | Q6PFX9 |
| B | Tankyrase-1 (EC 2.4.2.30) | protein | 311 | 54% helix, 0% strand | Q6PFX9 |
| C | Telomeric repeat-binding factor 1 | protein | 12 | 0% helix, 0% strand | P54274 |
| D | Telomeric repeat-binding factor 1 | protein | 11 | 0% helix, 0% strand | P54274 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 464 | 0.69 | 0.80 | 41 | empty |
| 2 | 95 | 0.33 | 0.73 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2186 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 668 Ų buried · 15 hydrogen bonds · protein-protein
- B–D · 640 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 5HKP · Crystal structure of mouse Tankyrase/human TRF1 complex · the same entry in another collection · chain D against D, TM-score 1.00
- Q6PFX9 · AlphaFold monomer V2.0 prediction for poly [ADP-ribose] polymerase tankyrase-1 (Q6PFX9) · a predicted model of the same protein · chain B against A, TM-score 0.70
- P54274 · AlphaFold monomer V2.0 prediction for telomeric repeat-binding factor 1 (P54274) · a predicted model of the same protein · chain C against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6PFX9
- Every structure of UniProt P54274
- Elsewhere: RCSB PDB 5HKP · PDBe 5HKP · UniProt Q6PFX9 · UniProt P54274
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.