GL1X · GenesisL1 explorer

MolNFT v1 · #121058 · protein + RNA

Structure of M. tuberculosis mazf-MT1 (RV2801C) in complex with RNA

5HJZ · Endoribonuclease MAZF9: “Structure of M. tuberculosis mazf-MT1 (RV2801C) in complex with RNA”. X-ray diffraction, 2 pockets (best druggability 0.49). MolNFT v1 #121058 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
5HJZ
Type
protein + RNA
Length
234 residues
Chains
3
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Endoribonuclease MAZF9; RNA (5'-R(*CP*AP*UP*C)-D(P*U)-R(P*AP*CP*CP*UP*GP*A)-3')
EC
3.1.-.-
UniProt
P71650
Pockets
2 · best druggability 0.49

Structure

x-ray diffraction · 3 distinct chains · 26% helix, 34% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AEndoribonuclease MAZF9 (EC 3.1.-.-)protein11426% helix, 34% strandP71650
BEndoribonuclease MAZF9 (EC 3.1.-.-)protein11626% helix, 34% strandP71650
CRNA (5'-R(*CP*AP*UP*C)-D(P*U)-R(P*AP*CP*CP*UP*GP*A)-3')rna4——

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
12210.490.7530empty
2560.460.8417empty

Interfaces

3 interfaces between chains.

  • A–B · 1473 Ų buried · 34 hydrogen bonds · protein-protein
  • A–C · 458 Ų buried · 20 hydrogen bonds · protein-nucleic
  • B–C · 176 Ų buried · 5 hydrogen bonds · protein-nucleic

Compared structures

  • 5HJZ · Structure of M. tuberculosis MazF-mt1 (Rv2801c) in complex with RNA · the same entry in another collection · chain A against A, TM-score 1.00
  • P71650 · AlphaFold monomer V2.0 prediction for endoribonuclease MAZF9 (P71650) · a predicted model of the same protein · chain B against A, TM-score 0.99

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