MolNFT v1 · #121029 · protein

Crystal structure of MIS18 'yippee-like' domain

5HJ0 · Kinetochore protein MIS18: “Crystal structure of MIS18 'yippee-like' domain”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.35). MolNFT v1 #121029 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5HJ0
Type: protein
Length: 300 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kinetochore protein MIS18
UniProt: Q9P802
Ligands: ZN
Pockets: 2 · best druggability 0.35

Structure

x-ray diffraction · 1 distinct chain · 12% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Kinetochore protein MIS18	protein	100	12% helix, 48% strand	Q9P802

Ligands and binding sites

ZN · Zinc ion · metal · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	75	0.35	0.76	21	empty
2	70	0.33	0.75	21	empty

Interfaces

2 interfaces between chains.

A–B · 740 Å² buried · 10 hydrogen bonds · protein-protein
B–C · 559 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

5HJ0 · Crystal Structure of Mis18 'Yippee-like' Domain · the same entry in another collection · chain A against A, TM-score 1.00
Q9P802 · AlphaFold monomer V2.0 prediction for kinetochore protein MIS18 (Q9P802) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9P802
Elsewhere: RCSB PDB 5HJ0 · PDBe 5HJ0 · UniProt Q9P802

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.