MolNFT v1 · #120948 · protein
HLA*A2402 complexed with HIV NEF138 10MER epitope
5HGH · HLA class I histocompatibility antigen, a-24 alpha chain: “HLA*A2402 complexed with HIV NEF138 10MER epitope”. X-ray diffraction, 4 pockets (best druggability 0.69). MolNFT v1 #120948 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5HGH
- Type
- protein
- Length
- 384 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I histocompatibility antigen, a-24 alpha chain; Beta-2-microglobulin; Protein…
- UniProt
- P05534, P61769, P18801
- Pockets
- 4 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HLA class I histocompatibility antigen, a-24 alpha chain | protein | 274 | 27% helix, 39% strand | P05534 |
| B | Beta-2-microglobulin | protein | 100 | 0% helix, 49% strand | P61769 |
| C | Protein nef | protein | 10 | 0% helix, 0% strand | P18801 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 621 | 0.69 | 0.78 | 56 | empty |
| 2 | 133 | 0.51 | 0.80 | 30 | empty |
| 3 | 178 | 0.47 | 0.76 | 30 | empty |
| 4 | 55 | 0.38 | 0.80 | 15 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1324 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 962 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05534
- Every structure of UniProt P61769
- Every structure of UniProt P18801
- Elsewhere: RCSB PDB 5HGH · PDBe 5HGH · UniProt P05534 · UniProt P61769 · UniProt P18801
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