MolNFT v1 · #12086 · protein
Crystal structure of the human argininosuccinate lyase Q286R mutant
1K62: “Crystal structure of the human argininosuccinate lyase Q286R mutant”. X-ray diffraction, 9 pockets (best druggability 0.49). MolNFT v1 #12086 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1K62
- Type
- protein
- Length
- 909 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Argininosuccinate lyase
- EC
- 4.3.2.1
- UniProt
- P04424
- Pockets
- 9 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 66% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Argininosuccinate lyase (EC 4.3.2.1) | protein | 450 | 67% helix, 5% strand | P04424 |
| B | Argininosuccinate lyase (EC 4.3.2.1) | protein | 459 | 65% helix, 5% strand | P04424 |
Pockets
9 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 205 | 0.49 | 0.75 | 29 | empty |
| 2 | 217 | 0.47 | 0.74 | 23 | empty |
| 3 | 77 | 0.45 | 0.82 | 17 | empty |
| 4 | 52 | 0.43 | 0.83 | 15 | empty |
| 5 | 70 | 0.41 | 0.80 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1794 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 1K62 · Crystal Structure of the Human Argininosuccinate Lyase Q286R Mutant · the same entry in another collection · chain A against A, TM-score 1.00
- P04424 · AlphaFold monomer V2.0 prediction for argininosuccinate lyase (P04424) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04424
- Elsewhere: RCSB PDB 1K62 · PDBe 1K62 · UniProt P04424
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