MolNFT v1 · #120807 · protein
Structure of eav NSP11 H141A mutant at 3.10A
5HC1 · Non-structural protein 11: “Structure of eav NSP11 H141A mutant at 3.10A”. X-ray diffraction, 12 pockets (best druggability 0.53). MolNFT v1 #120807 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5HC1
- Type
- protein
- Length
- 876 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-structural protein 11
- UniProt
- P19811
- Pockets
- 12 · best druggability 0.53
Structure
x-ray diffraction · 4 distinct chains · 15% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Non-structural protein 11 | protein | 219 | 14% helix, 28% strand | P19811 |
| B | Non-structural protein 11 | protein | 219 | 15% helix, 30% strand | P19811 |
| C | Non-structural protein 11 | protein | 218 | 14% helix, 33% strand | P19811 |
| D | Non-structural protein 11 | protein | 220 | 15% helix, 33% strand | P19811 |
Pockets
12 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 282 | 0.53 | 0.75 | 50 | empty |
| 2 | 142 | 0.40 | 0.74 | 32 | empty |
| 3 | 92 | 0.36 | 0.75 | 26 | empty |
| 4 | 61 | 0.35 | 0.78 | 14 | empty |
| 5 | 50 | 0.33 | 0.78 | 15 | empty |
Interfaces
5 interfaces between chains.
- B–C · 706 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 704 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 610 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 607 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 428 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5HC1 · Structure of EAV NSP11 H141A mutant at 3.10A · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19811
- Elsewhere: RCSB PDB 5HC1 · PDBe 5HC1 · UniProt P19811
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