MolNFT v1 · #120805 · protein
Structure of eav NSP11 K170A mutant at 3.10A
5HBZ · Non-structural protein 11: “Structure of eav NSP11 K170A mutant at 3.10A”. X-ray diffraction, 9 pockets (best druggability 0.65). MolNFT v1 #120805 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5HBZ
- Type
- protein
- Length
- 1,286 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-structural protein 11
- UniProt
- P19811
- Pockets
- 9 · best druggability 0.65
Structure
x-ray diffraction · 3 distinct chains · 14% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Non-structural protein 11 | protein | 219 | 16% helix, 37% strand | P19811 |
| D, E | Non-structural protein 11 | protein | 209 | 12% helix, 33% strand | P19811 |
| F | Non-structural protein 11 | protein | 211 | 14% helix, 34% strand | P19811 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 323 | 0.65 | 0.81 | 39 | empty |
| 2 | 177 | 0.59 | 0.82 | 29 | empty |
| 3 | 205 | 0.58 | 0.80 | 29 | empty |
| 4 | 398 | 0.58 | 0.75 | 50 | empty |
| 5 | 322 | 0.57 | 0.76 | 39 | empty |
Interfaces
8 interfaces between chains.
- C–E · 808 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 783 Ų buried · 4 hydrogen bonds · protein-protein
- B–F · 753 Ų buried · 5 hydrogen bonds · protein-protein
- A–E · 603 Ų buried · 2 hydrogen bonds · protein-protein
- C–F · 403 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 5HBZ · Structure of EAV NSP11 K170A mutant at 3.10A · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19811
- Elsewhere: RCSB PDB 5HBZ · PDBe 5HBZ · UniProt P19811
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