MolNFT v1 · #120800 · protein + DNA
Structure of the E. COLI nucleoid occlusion protein slma bound to DNA and the C-terminal tail of the cytoskeletal cell division protein ftsz
5HBU · Nucleoid occlusion factor slma: “Structure of the E. COLI nucleoid occlusion protein slma bound to DNA and the C-terminal tail of the…”. X-ray diffraction, 19 pockets (best druggability 0.77). MolNFT v1 #120800 on GenesisL1: 3D…
- PDB
- 5HBU
- Type
- protein + DNA
- Length
- 1,580 residues
- Chains
- 13
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoid occlusion factor slma; DNA (5'-D(*GP*TP*GP*AP*GP*TP*AP*CP*TP*CP*AP*C)-3'); Ftsz…
- UniProt
- P0C093
- Pockets
- 19 · best druggability 0.77
Structure
x-ray diffraction · 5 distinct chains · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G, H | Nucleoid occlusion factor slma | protein | 190 | 69% helix, 0% strand | P0C093 |
| B | Nucleoid occlusion factor slma | protein | 196 | 69% helix, 0% strand | P0C093 |
| D, F | Nucleoid occlusion factor slma | protein | 189 | 75% helix, 0% strand | P0C093 |
| W, Z, R, T | DNA (5'-D(*GP*TP*GP*AP*GP*TP*AP*CP*TP*CP*AP*C)-3') | dna | 12 | — | — |
| K | Ftsz ctt peptide | protein | 8 | 0% helix, 0% strand | — |
Pockets
19 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1170 | 0.77 | 0.79 | 104 | empty |
| 2 | 398 | 0.61 | 0.77 | 42 | empty |
| 3 | 294 | 0.51 | 0.75 | 28 | empty |
| 4 | 310 | 0.51 | 0.74 | 25 | empty |
| 5 | 73 | 0.50 | 0.85 | 17 | empty |
Interfaces
30 interfaces between chains.
- A–B · 1860 Ų buried · 28 hydrogen bonds · protein-protein
- C–D · 1762 Ų buried · 33 hydrogen bonds · protein-protein
- E–F · 1755 Ų buried · 33 hydrogen bonds · protein-protein
- G–H · 1750 Ų buried · 30 hydrogen bonds · protein-protein
- F–K · 604 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 5HBU · Structure of the E. coli nucleoid occlusion protein SlmA bound to DNA and the C-terminal… · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C093
- Elsewhere: RCSB PDB 5HBU · PDBe 5HBU · UniProt P0C093
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