MolNFT v1 · #120673 · protein

Structure of full-length extracellular domain of hai-1 at pH 4.6

5H7V · Kunitz-type protease inhibitor 1: “Structure of full-length extracellular domain of hai-1 at pH 4.6”. X-ray diffraction, 4 pockets (best druggability 0.76). MolNFT v1 #120673 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 5H7V
Type: protein
Length: 320 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kunitz-type protease inhibitor 1
UniProt: O43278
Pockets: 4 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 12% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Kunitz-type protease inhibitor 1	protein	320	12% helix, 25% strand	O43278

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1085	0.76	0.78	76	empty
2	111	0.72	0.92	20	empty
3	315	0.69	0.83	39	empty
4	68	0.52	0.85	20	empty

Modifications

Observed in the structure: 10 disulfide (disulfide).

Compared structures

5H7V · Structure of full-length extracellular domain of HAI-1 at pH 4.6 · the same entry in another collection · chain A against A, TM-score 1.00
O43278 · AlphaFold monomer V2.0 prediction for kunitz-type protease inhibitor 1 (O43278) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43278
Elsewhere: RCSB PDB 5H7V · PDBe 5H7V · UniProt O43278

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