MolNFT v1 · #120603 · protein
A cyclic-gmp-dependent signalling pathway regulates bacterial phytopathogenesis
5H5O · Diguanylate cyclase: “A cyclic-gmp-dependent signalling pathway regulates bacterial phytopathogenesis”. X-ray diffraction, 1 ligand (PCG), 1 pocket (best druggability 0.74). MolNFT v1 #120603 on GenesisL1: 3D structure, binding…
- PDB
- 5H5O
- Type
- protein
- Length
- 248 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Diguanylate cyclase
- UniProt
- B0RM05
- Ligands
- PCG
- Pockets
- 1 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Diguanylate cyclase | protein | 125 | 33% helix, 28% strand | B0RM05 |
| B | Diguanylate cyclase | protein | 123 | 33% helix, 27% strand | B0RM05 |
Ligands and binding sites
- PCG · Cyclic guanosine monophosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 374 | 0.74 | 0.85 | 55 | PCG |
Interfaces
1 interface between chains.
- A–B · 848 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 5H5O · A cyclic-GMP-dependent signalling pathway regulates bacterial phytopathogenesis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B0RM05
- Elsewhere: RCSB PDB 5H5O · PDBe 5H5O · UniProt B0RM05
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